Sunday, January 31, 2010

Ephedrine, Phenylephrine, Pseudoephrine

These chemicals are alpha-1 Norepinephrine receptor agonists. Alpha-1 Norepinephrine receptors are Gq mediated. That is, they call upon the Phospholipase-C pathway, leading to IP3 and DAG. Calcium release is produced, as well as the phosphorylating effects of PKC.

Ephedrine-class compounds are used to treat the effects of hypotension. It is also an appetite supressant (consider Fen-Phen).

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